Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages. The biosyntheses of polyketides share striking similarities with fatty acid biosynthesis. The PKS … See more PKSs can be classified into three types: • Type I PKSs are large, complex protein structures with multiple modules which in turn consist of several domains that are usually covalently connected to each other and fulfill different … See more Each type I polyketide-synthase module consists of several domains with defined functions, separated by short spacer regions. The order of modules and domains of a complete polyketide-synthase is as follows (in the order N-terminus See more Only about 1% of all known molecules are natural products, yet it has been recognized that almost two thirds of all drugs currently in … See more • Doxorubicin See more The growing chain is handed over from one thiol group to the next by trans-acylations and is released at the end by hydrolysis or by cyclization (alcoholysis or aminolysis See more Polyketide synthases are an important source of naturally occurring small molecules used for chemotherapy. For example, many of the commonly used antibiotics, such as See more • Polyketide+synthases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more WebMar 6, 2015 · Think again: The thioesterase/cyclase enzyme of the elaiophylin polyketide synthase catalyzes symmetric diolide formation in vitro from a synthetic pentaketide substrate by an iterative mechanism. Unexpectedly, a tetraketide that is not itself a substrate can be co-opted in the presence of the pentaketide to produce an asymmetric macrodiolide.

An artificial pathway for polyketide biosynthesis Nature Catalysis

WebJan 23, 2024 · A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis. Enacyloxin IIa is an antibiotic, assembled by a modular polyketide synthase, ... WebDec 18, 2014 · This unique mechanism of transfer of PKS products in mycobacteria appears as an extension of the macrocyclisation mechanism, catalyzed by many TE domains, … rawlings heart of the hide pitching gloves

Unraveling the iterative type I polyketide synthases hidden in ... - PNAS

WebAug 12, 2024 · Modular polyketide synthases (PKSs) produce complex, bioactive secondary metabolites in assembly line-like multistep reactions. Longstanding efforts to produce novel, biologically active compounds by recombining intact modules to new modular PKSs have mostly resulted in poorly active chimeras and decreased product yields. Recent findings … WebJul 28, 2009 · Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a pathway to … WebA Polyketide Synthase Acyltransferase Domain Structure Suggests a Recognition Mechanism for Its Hydroxymalonyl-Acyl Carrier Protein Substrate Hyunjun Park, Brian M. Kevany¤a, David H. Dyer¤b ... simple good small toaster oven