Ionophore nigericin
Web1 feb. 1978 · Nigericin, an ionophore that exchanges K+ for H+ across most biologic membranes, reversibly inhibited the proliferative response of human lymphocytes … WebVaccinia virus is the prototypic member of the Orthopoxvirus genus, which also includes variola and monkeypox virus. In this study, we demonstrate that the carboxylic ionophore nigericin is a potent inhibitor of vaccinia virus replication in several human cell lines. In HeLa cells, we found that the 50% inhibitory concentration of nigericin ...
Ionophore nigericin
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http://www.cnreagent.com/s/sv75647.html WebNigericin sodium salt is a potassium ionophore, exchanges K + for H + across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral …
Web15 apr. 2016 · The role of carboxylic ionophores (including nigericin and monensin) in lysosomal protein degradation was shown previously, and interestingly monensin inhibited autophagy (29). Thus, monensin and nigericin produced opposite effects on pH and on autophagy and mitophagy that again, suggests the effect of intracellular pH on …
Web25 sep. 2024 · Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei parasites. The T. brucei aquaglyceroporin isoform 2, TbAQP2, has been linked to the uptake of pentamidine. Negative membrane potentials and transmembrane pH gradients were suggested to promote transport of the dicationic antitrypanosomal drug. Application of … WebNigericin has been employed to study anion transport (Section 2.5) and to modify the pH gradient across energy-conserving membranes. It is often stated that nigericin abolishes ΔpH across a membrane; in fact, the ionophore equalises the K + and H + concentration gradients, with the final ion gradients depending on the experimental conditions.
WebNigericin is an antibiotic isolated Streptomyces hygroscopicusthat acts as an H+, K+, Na+, Pb2+ionophore. Similarly to Valinomycin (Prod. No. BML-KC140), Nigericin is most …
WebAbstract Emerging studies have shown that nigericin, an H +, K + and Pb 2+ ionophore, has exhibited a promising anti-cancer activity in various cancers. However, its anti … dark blue microphoneWebIn summary care must be taken when using the putative K+/H+ ionophore nigericin as an experimental tool in synaptosomes, as under standard conditions (i.e. in the presence of high external Na+) nigericin behaves as a Na+/H+ ionophore. Publication types Research Support, Non-U.S. Gov't MeSH terms Animals bisbee credit unionWebThe Ca 2+ ionophore A23187 has been used extensively to permit entry of Ca 2+ into cells, which normally have a low native permeability to Ca 2+, ... Nigericin exchanges K + for protons and has been used in many studies of mitochondrial bioenergetics to alter electrical and chemical gradients for protons. bisbee county jail addressWebNigericin, an ionophore that exchanges K+ for H+ across most biologic membranes, reversibly inhibited the proliferative response of human lymphocytes to phytohemagglutinin (PHA). Inhibition occurred at nigericin concentrations of 10 (-8) M or greater, and only during the early event of mitogenesis. bisbee court calendarWebThe ionophore nigericin equilibrates pH across cells so that the final ion gradients depend on the experimental conditions . Fluorescence intensity was measured in triplicate using the Varioskan LUX Multimode Microplate Reader (Thermo Fisher Scientific) for light emitted at 440 nm and 540 nm with reference excitation wavelengths of 329 nm and 384 nm, … bisbee daily review archivesWebToxins 2013, 5 1168 control of serum-response element (SRE). All dermonecrotic toxins carry a glutamine deamidase activity at their C-terminus that activates their G-protein target substrates and use their N-terminus as the machinery for binding to cells and facilitating membrane translocation of their cargo (activity bisbee crimeWeb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 bisbee courthouse wedding