WebCT-FIRE reads MATLAB-supported image files and extracts individual collagen fibers using a combination method that we call CT-FIRE (ctFIRE) in software implementation. The CT-FIRE approach is described in publication1, which combines the benefits of fast discrete curvelet transform2 for image denuclearization, improved fiber edge functions, and ... WebMar 12, 2024 · For each collagen fiber descriptor, cut-off values were computed by maximizing the Youden’s index J, which is defined as J = Sensitivity + Specificity – 1 (40, 41). Association analyses between collagen fiber descriptors and clinicopathologic variables were conducted as described (6). In brief, associations between quantitative …
A subset of myofibroblastic cancer-associated fibroblasts regulate ...
WebSep 4, 2015 · Of the four collagen metrics, collagen fiber length had the most value in differentiating the regions with an area under the curve of 0.733 for pancreatic ductal adenocarcinoma vs benign and 0.701 ... WebSecond harmonic generation (SHG) images of valve sections were acquired and collagen fiber characteristics analyzed through the use of ctFIRE and CurveAlign software. Immunohistological staining and qRT-PCR were used to determine the expression of proteins known to crosslink collagen, such as PLOD1 and lysyl oxidase (LOX). darwin\\u0027s house
CT-FIRE V2.0 BETA (12/2024) Manual and Tutorials
WebCollagen Collagen is the most abundant protein in the body. Its fiber-like structure is used to make connective tissue. Like the name implies, this type of tissue connects other tissues and is a major component of bone, skin, muscles, tendons, and cartilage. It helps to make tissues strong and resilient, able to withstand stretching. WebNov 15, 2024 · Type I collagen fiber is the most common type, and is found in skin, tendons, and ligaments. Type II collagen fiber is more elastic and softer, found in nose and ears. Type III collagen is found ... WebDec 30, 2015 · Quantitative measures of collagen fiber morphology were used to stratify patients showing that increased collagen fiber length correlates with significantly poorer survival rates (Log-rank p < 0.05). darwin\\u0027s houston