WebThe cSH2 domain binds to the kinase domain and sterically blocks the active site of the enzyme. This finding is in accord with the enzyme-inhibitory activity of Nb3-142. The docked position of the cSH2 domain corresponds to the position of the ED2 seen previously in the BYL-719–bound structure . The BH domain is located below the C2, helical ... WebDec 1, 2024 · The deletions of the combined cSH2 and iSH2 domains and also the deletion of the cSH2, iSH2 and nSH2 domains yield results that go in the same direction, generally activating in p85α and reducing ...
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